A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis.

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第一作者： Chen,Jin

第一单位： Department of Orthopedic, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.

作者： Chen,Jin ^[1] ; Kai,Tan ^[2] ; Zhe,Yao ^[1] ; Bing-Hao,Lin ^[2] ; Du-Piao,Zhang ^[2] ; Wei-Kai,Chen ^[3] ; Shu-Ming,Mao ^[1] ; Wei,Zhang ^[2] ; Liang,Chen ^[1] ; Zhen,Lin ^[2] ; She-Ji,Weng ^[4] ; Bing-Li,Bai ^[1] ; Wen-Hao,Zheng ^[2] ; Gang,Zheng ^[1] ; Zong-Yi,Wu ^[2] ; Lei,Yang ^[5]

作者单位： Department of Orthopedic, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China. ^[1] Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou 325000, China. ^[2] Department of Burn and Wound Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. ^[3] School of Medicine, Shanghai University, Shanghai 200444, China. ^[4] Orthopaedic Oncology Services, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China. ^[5]

关键词 AMPK/SIRT1 pathway ferroptosis mitochondrial dysfunction type 2 diabetic osteoporosis vitamin K2

主题词小鼠(Mice);动物(Animals);维生素K2(Vitamin K 2);AMP活化蛋白激酶类(AMP-Activated Protein Kinases);抗衰老酶1(Sirtuin 1);骨质疏松(Osteoporosis);糖尿病, 2型(Diabetes Mellitus, Type 2)

DOI 10.1021/acs.jafc.2c05632

PMID 36719855

发布时间 2023-02-16

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