首页> Immunity> The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.

The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon.

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第一作者： Lingjia,Kong

第一单位： Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

作者： Lingjia,Kong ^[1] ; Vladislav,Pokatayev ^[2] ; Ariel,Lefkovith ^[3] ; Grace T,Carter ^[3] ; Elizabeth A,Creasey ^[4] ; Chirag,Krishna ^[3] ; Sathish,Subramanian ^[5] ; Bharati,Kochar ^[6] ; Orr,Ashenberg ^[3] ; Helena,Lau ^[3] ; Ashwin N,Ananthakrishnan ^[6] ; Daniel B,Graham ^[1] ; Jacques,Deguine ^[3] ; Ramnik J,Xavier ^[7]

作者单位： Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. ^[1] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. ^[2] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ^[3] Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ^[4] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ^[5] Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA. ^[6] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu. ^[7]

关键词 Crohn's disease IBD high-dimensional profiling inflammation inflammatory bowel disease myofibroblasts single-cell RNA sequencing

医学主题词人类(Humans);Crohn病(Crohn Disease);结肠(Colon);回肠(Ileum);炎症(Inflammation);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1016/j.immuni.2023.01.002

PMID 36720220

发布时间 2024-09-23

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