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Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth.

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第一作者: Emma,Scott
第一单位: Newcastle University Centre for Cancer, Newcastle University Institute of Biosciences, Newcastle, NE1 3BZ, UK.
作者单位: Newcastle University Centre for Cancer, Newcastle University Institute of Biosciences, Newcastle, NE1 3BZ, UK. [1] The Chemical Glycobiology Laboratory, The Francis Crick Institute, NW1 1AT, London, UK.;Department of Chemistry, Imperial College London, W12 0BZ, London, UK. [2] Cellular Pathology, The Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK. [3] Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, Palo Alto, CA, 94304, USA. [4] Molecular Diagnostics and Therapeutics Group, Charles Bell House, Division of Surgery and Interventional Science, University College London, London, UK. [5] Department of Life Technologies, Division of Biotechnology, University of Turku, Turku, Finland. [6] Department of Urologic Sciences, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada.;Vancouver Prostate Centre, Vancouver, BC, V6H 3Z6, Canada. [7] Institute for Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK. [8] Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Paul O'Gorman Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. [9] Cancer Research Unit, Department of Biology, University of York, Heslington, North Yorkshire, YO10 5DD, UK. [10] The Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK. [11] Structural Biology Science Technology Platform, The Francis Crick Institute, NW1 1AT, London, UK. [12] Sarafan Chem-H and Departemnt of Chemistry, Stanford University, 424 Santa Teresa St, Stanford, CA, 94305, USA. [13] Department of Pathology, UCLH NHS Foundation Trust, London, UK. [14] UCL Centre for Medical Imaging, Charles Bell House, University College London, London, UK. [15] NIHR Exeter Clinical Research Facility, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. [16] Department of Pathology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. [17] Exeter Surgical Health Services Research Unit, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. [18] Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Exeter, UK. [19] Division of Clinical Studies, The Institute of Cancer Research, London, SM2 5NG, UK. [20] Division of Clinical Studies, The Institute of Cancer Research, London, SM2 5NG, UK.;Prostate Cancer Targeted Therapy Group, The Royal Marsden Hospital, London, SM2 5PT, UK. [21] University of British Columbia, Faculty of Pharmaceutical Sciences, Vancouver, BC, V6T 1Z3, Canada. [22] Howard Hughes Medical Institute, 424 Santa Teresa St, Stanford, CA, 94305, USA. [23] Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Paul O'Gorman Building, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.;Department of Urology, Freeman Hospital, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE7 7DN, UK. [24] University of Zaragoza, Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza, Spain; Fundación ARAID, 50018, Zaragoza, Spain.;Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark. [25] Department of Life Technologies, Division of Biotechnology, University of Turku, Turku, Finland.;InFLAMES Research Flagship Center, University of Turku, Turku, Finland. [26] Newcastle University Centre for Cancer, Newcastle University Institute of Biosciences, Newcastle, NE1 3BZ, UK. Jennifer.munkley@ncl.ac.uk. [27]
DOI 10.1038/s41388-023-02604-x
PMID 36725887
发布时间 2025-05-30
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