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Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation.

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第一作者： Keisuke,Seike

第一单位： Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA.

作者： Keisuke,Seike ^[1] ; Anders,Kiledal ^[2] ; Hideaki,Fujiwara ^[3] ; Israel,Henig ^[4] ; Marina,Burgos da Silva ^[5] ; Marcel R M,van den Brink ^[5] ; Robert,Hein ^[2] ; Matthew,Hoostal ^[6] ; Chen,Liu ^[7] ; Katherine,Oravecz-Wilson ^[1] ; Emma,Lauder ^[1] ; Lu,Li ^[1] ; Yaping,Sun ^[1] ; Thomas M,Schmidt ^[6] ; Yatrik M,Shah ^[8] ; Robert R,Jenq ^[9] ; Gregory,Dick ^[2] ; Pavan,Reddy ^[10]

作者单位： Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA. ^[1] Department of Earth & Environmental Sciences, University of Michigan, Ann Arbor, MI 48109, USA. ^[2] Department of Hematology and Oncology, Okayama University Hospital, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan. ^[3] Department of Hematology, Rambam Health Care Campus, Haifa, Israel. ^[4] Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[5] Department of Internal Medicine, Division of Infectious Disease, University of Michigan Health System, Ann Arbor, MI, USA. ^[6] Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. ^[7] Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI, USA; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA. ^[8] Department of Genomic Medicine, Division of Cancer Medicine, MD Anderson Cancer Center, Houston, TX, USA. ^[9] Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. Electronic address: pavan.reddy@bcm.edu. ^[10]

关键词 T cell-mediated gastrointestinal (GI) diseases allogeneic germ-free graft-versus-host host disease hypoxia iron chelation microbiome oxygen tissue tolerance transplantation

医学主题词动物(Animals);小鼠(Mice);造血干细胞移植(Hematopoietic Stem Cell Transplantation);肠(Intestines);移植物抗宿主病(Graft vs Host Disease);胃肠疾病(Gastrointestinal Diseases)

DOI 10.1016/j.immuni.2023.01.007

PMID 36736321

发布时间 2024-05-18

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