Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY.

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作者： Colin Y,Kim ^[1] ; Andrew J,Mitchell ^[2] ; David W,Kastner ^[1] ; Claire E,Albright ^[2] ; Michael A,Gutierrez ^[3] ; Christopher M,Glinkerman ^[1] ; Heather J,Kulik ^[1] ; Jing-Ke,Weng ^[1]

作者单位： Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA. ^[1] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. ^[2] Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. ^[3] Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA. wengj@wi.mit.edu. ^[4] Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. wengj@wi.mit.edu. ^[5]

主题词质子(Protons);异构现象(Isomerism);植物(Plants);酰基转移酶类(Acyltransferases);香豆素类(Coumarins)

DOI 10.1038/s41467-023-36299-1

PMID 36737607

发布时间 2023-03-08

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