Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses.

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第一作者： Yi-Ju,Li

第一单位： Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.

作者： Yi-Ju,Li ^[1] ; Karen,Nuytemans ^[2] ; Jong Ok,La ^[3] ; Rong,Jiang ^[4] ; Susan H,Slifer ^[2] ; Shuming,Sun ^[2] ; Adam,Naj ^[5] ; Xiaoyi Raymond,Gao ^[4] ; Eden R,Martin ^[2]

作者单位： Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA. ^[1] Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA. ^[2] John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA. ^[3] John T. MacDonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA. ^[4] Department of Psychiatry and Behavior Science, Duke University School of Medicine, Durham, North Carolina, USA. ^[5] Department of Biostatistics, Epidemiology, and Informatics, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. ^[6] Department of Ophthalmology and Visual Sciences, Division of Human Genetics, The Ohio State University, Columbus, Ohio, USA. ^[7] Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA. ^[8]

关键词 Alzheimer's disease age at onset genetic association polygenic risk score quantitative trait survival model