DoE development of ionic gradient liposomes: A successful approach to improve encapsulation, prolong anesthesia and decrease the toxicity of etidocaine.

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作者： Juliana Damasceno,Oliveira ^[1] ; Gustavo Henrique,Rodrigues da Silva ^[1] ; Ludmila David,de Moura ^[1] ; Gabriela,Göethel ^[2] ; Juliana Z B,Papini ^[3] ; Bruna Renata,Casadei ^[4] ; Ligia Nunes de Morais,Ribeiro ^[5] ; Luis Fernando,Cabeça ^[6] ; Solange Cristina,Garcia ^[2] ; Elizabeth Ferreira,Martinez ^[3] ; Giovana Radomille,Tofoli ^[3] ; Eneida,de Paula ^[7]

作者单位： Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, SP, Brazil. ^[1] Toxicology Laboratory, Pharmacy Faculty, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. ^[2] São Leopoldo Mandic Institute and Research Center, Campinas-São Paulo, Brazil. ^[3] Physics Institute, University of São Paulo, Brazil. ^[4] Institute of Biotechnology Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil. ^[5] Department of Chemistry, Federal Technological University of Parana, Londrina, PR, Brazil. ^[6] Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (Unicamp), Campinas, SP, Brazil. Electronic address: depaula@unicamp.br. ^[7]

关键词 Drug delivery Etidocaine Ionic gradient liposomes Local anesthetics Toxicity

主题词大鼠(Rats);动物(Animals);脂质体(Liposomes);依替卡因(Etidocaine);麻醉药, 局部(Anesthetics, Local);麻醉(Anesthesia);离子(Ions)

DOI 10.1016/j.ijpharm.2023.122672

PMID 36738810

发布时间 2023-02-24

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