Oxidized mitochondrial DNA: a protective signal gone awry.

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作者： Hongxu,Xian ^[1] ; Michael,Karin ^[2]

作者单位： Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA. ^[1] Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA. Electronic address: karinoffice@ucsd.edu. ^[2]

关键词 NLRP3 inflammasome Ox-mtDNA autoimmunity cGAS–STING cell-free DNA immunopathology inflammation stressed mitochondria

主题词人类(Humans);DNA, 线粒体(DNA, Mitochondrial);炎性体(Inflammasomes);信号传导(Signal Transduction);线粒体(Mitochondria);免疫, 先天(Immunity, Innate)

DOI 10.1016/j.it.2023.01.006

PMID 36739208

发布时间 2023-05-21

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