A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection.

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作者： Rani,Burm ^[1] ; Freya,Van Houtte ^[1] ; Lieven,Verhoye ^[1] ; Ahmed Atef,Mesalam ^[2] ; Sandra,Ciesek ^[3] ; Philippe,Roingeard ^[4] ; Heiner,Wedemeyer ^[5] ; Geert,Leroux-Roels ^[6] ; Philip,Meuleman ^[1]

作者单位： Laboratory of Liver Infectious Diseases (LLID), Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. ^[1] Laboratory of Liver Infectious Diseases (LLID), Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.;Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), Dokki, Cairo 12622, Egypt. ^[2] Institute for Medical Virology, University Hospital, Goethe University, Frankfurt am Main, Germany.;German Center for Infection Research, DZIF, External Partner Site, Frankfurt am Main, Germany.;Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Theodor Stern Kai 7, Frankfurt am Main, Germany. ^[3] INSERM U966, Université François Rabelais and CHRU de Tours, Tours, France. ^[4] Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. ^[5] Center for Vaccinology, Faculty of Medicine and Health Sciences, Ghent University and University Hospital, Ghent, Belgium. ^[6]

关键词 HBsAg, hepatitis B surface antigen IC50, half maximal inhibitory concentration IP, intraperitoneally LLOQ, lower limit of quantification LOD, limit of detection NTCP, sodium taurocholate co-transporting polypeptide Viral hepatitis hepatitis B hepatitis B surface antigen hepatitis D hu-mAb, human monoclonal antibody human monoclonal antibody human-liver chimeric mouse model neutralization prevention

DOI 10.1016/j.jhepr.2022.100646

PMID 36748051

发布时间 2024-09-12

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JHEP reports

2023年5卷3期

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A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection.

JHEP reports

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A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection.

JHEP reports

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JHEP reports

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