2,3-Diarylindoles as COX-2 Inhibitors: Exploring the Structure-activity Relationship through Molecular Docking Simulations.

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第一作者： Andrea,Cuppoloni

第一单位： Department of Pharmacy, School of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, Brazil.

作者： Andrea,Cuppoloni ^[1] ; João Vitor,Silva ^[1] ; Timothy James,Snape ^[2] ; Samridhi,Lal ^[3] ; Jeanine,Giarolla ^[1]

作者单位： Department of Pharmacy, School of Pharmaceutical Sciences, University of Sao Paulo, São Paulo, Brazil. ^[1] Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK. ^[2] Amity Institute of Pharmacy, Samridhi Lal, Amity University, Gurugram, India. ^[3]

关键词 2 3-diarylindoles Anti-inflammatory compounds.COX-2 inhibitors Drug design Ligand interactions Molecular docking simulations SAR

主题词环氧化酶2抑制剂(Cyclooxygenase 2 Inhibitors);环氧化酶2(Cyclooxygenase 2);构效关系(Structure-Activity Relationship);模型, 分子(Models, Molecular);药物设计(Drug Design);分子结构(Molecular Structure);剂量效应关系, 药物(Dose-Response Relationship, Drug)

DOI 10.2174/1568026623666230207120752

PMID 36748812

发布时间 2023-07-21

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