The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act.

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作者： Margaret,Moline ^[1] ; Shoji,Asakura ^[2] ; Carsten,Beuckman ^[3] ; Ishani,Landry ^[4] ; Beatrice,Setnik ^[5] ; Judy,Ashworth ^[6] ; Jack E,Henningfield ^[6]

作者单位： Eisai Inc., 200 Metro Boulevard, Nutley, Jersey, NJ, 07110, USA. Margaret_Moline@eisai.com. ^[1] Eisai Co., Ltd., Tsukuba, Japan. ^[2] Formerly Eisai Co., Ltd., Tsukuba, Japan. ^[3] Formerly Eisai, Nutley, Jersey, NJ, USA. ^[4] Altasciences, Laval, Quebec, Canada and the Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. ^[5] Pinney Associates, Inc., Bethesda, MD, USA. ^[6] The Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[7]

关键词 Abuse potential Controlled Substances Act Dependence potential Drug abuse Dual orexin receptor antagonist Human Hypnotics Lemborexant Monkey Rat

主题词成年人(Adult);人类(Humans);入睡和睡眠障碍(Sleep Initiation and Maintenance Disorders);吡啶类(Pyridines);催眠药和镇静药(Hypnotics and Sedatives)

DOI 10.1007/s00213-023-06320-y

PMID 36749354

发布时间 2023-04-27

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准确一般字义偏差语意偏离译文作用小提交