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Selective suppression of de novo SARS-CoV-2 vaccine antibody responses in patients with cancer on B cell-targeted therapy.

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第一作者： Joseph H,Azar

第一单位： Division of Medical Oncology, Department of Internal Medicine.;The Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - James.

作者： Joseph H,Azar ^[1] ; John P,Evans ^[2] ; Madison H,Sikorski ^[1] ; Karthik B,Chakravarthy ^[1] ; Selah,McKenney ^[1] ; Ian,Carmody ^[1] ; Cong,Zeng ^[3] ; Rachael,Teodorescu ^[1] ; No-Joon,Song ^[1] ; Jamie L,Hamon ^[4] ; Donna,Bucci ^[1] ; Maria,Velegraki ^[1] ; Chelsea,Bolyard ^[4] ; Kevin P,Weller ^[4] ; Sarah A,Reisinger ^[5] ; Seema A,Bhat ^[6] ; Kami J,Maddocks ^[6] ; Nathan,Denlinger ^[6] ; Narendranath,Epperla ^[6] ; Richard J,Gumina ^[7] ; Anastasia N,Vlasova ^[8] ; Eugene M,Oltz ^[9] ; Linda J,Saif ^[8] ; Dongjun,Chung ^[10] ; Jennifer A,Woyach ^[6] ; Peter G,Shields ^[1] ; Shan-Lu,Liu ^[11] ; Zihai,Li ^[1] ; Mark P,Rubinstein ^[1]

作者单位： Division of Medical Oncology, Department of Internal Medicine.;The Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - James. ^[1] Center for Retrovirus Research.;Department of Veterinary Biosciences.;Molecular, Cellular and Developmental Biology Program. ^[2] Center for Retrovirus Research.;Department of Veterinary Biosciences. ^[3] The Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - James. ^[4] The Ohio State University Comprehensive Cancer Center - James, The James Cancer Hospital. ^[5] Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center - James. ^[6] Department of Internal Medicine, Division of Cardiovascular Medicine; and. ^[7] Center for Food Animal Health, Animal Sciences Department, Ohio Agricultural Research and Development Center, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Columbus, Ohio, USA.;Veterinary Preventive Medicine Department, College of Veterinary Medicine, The Ohio State University, Wooster, Ohio, USA.;Viruses and Emerging Pathogens Program, Infectious Diseases Institute. ^[8] The Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - James.;Department of Microbial Infection and Immunity; and. ^[9] The Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center - James.;Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA. ^[10] Center for Retrovirus Research.;Department of Veterinary Biosciences.;Viruses and Emerging Pathogens Program, Infectious Diseases Institute.;Department of Microbial Infection and Immunity; and. ^[11]

关键词 COVID-19 Cancer Immunoglobulins Oncology

医学主题词人类(Humans);抗体生成(Antibody Formation);肿瘤(Neoplasms);抗体, 单克隆(Antibodies, Monoclonal);抗体, 病毒(Antibodies, Viral)

DOI 10.1172/jci.insight.163434

PMID 36749632

发布时间 2023-09-19

基金项目

P30 CA016058/CA/NCI NIH HHS/United States R01 AI150473/AI/NIAID NIH HHS/United States R01 CA222817/CA/NCI NIH HHS/United States U54 CA260582/CA/NCI NIH HHS/United States

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Selective suppression of de novo SARS-CoV-2 vaccine antibody responses in patients with cancer on B cell-targeted therapy.

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Selective suppression of de novo SARS-CoV-2 vaccine antibody responses in patients with cancer on B cell-targeted therapy.

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