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Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule.

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第一作者: Fei,Yuan
第一单位: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
作者: Fei,Yuan [1] ; Yana,Li [2] ; Rui,Hu [3] ; Mengting,Gong [4] ; Mengyao,Chai [1] ; Xuefei,Ma [2] ; Jiaxue,Cha [1] ; Pan,Guo [2] ; Kaijiang,Yang [1] ; Mushan,Li [2] ; Minglu,Xu [5] ; Qing,Ma [6] ; Qiang,Su [6] ; Chuan,Zhang [1] ; Zhejin,Sheng [2] ; Heng,Wu [7] ; Yuan,Wang [1] ; Wen,Yuan [2] ; Shan,Bian [1] ; Li,Shao [2] ; Ru,Zhang [1] ; Kaicheng,Li [2] ; Zhen,Shao [8] ; Zhen-Ning,Zhang [1] ; Weida,Li [2]
作者单位: Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. [1] Tsingtao Advanced Research Institute, Tongji University, Qingdao, 266071, China. [2] CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. [3] University of Chinese Academy of Sciences, Beijing, 100049, China. [4] QuietD Biotechnology, Ltd., Shanghai, 201210, China. [5] Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. [6] Department of Statistics, The Pennsylvania State University, University Park, PA, 16802, USA. [7] School of Medicine, Tongji University, Shanghai, 200092, China. [8] Department of Psychosomatic Medicine, Shanghai Tongji Hospital, Tongji University School of Medicine, Shanghai, 200092, China. [9] Department of Neurology and Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and National Collaborative Innovation Center, Chengdu, Sichuan, 610041, China. [10] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA. [11] Department of VIP Clinic, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China. [12] CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. shaozhen@picb.ac.cn. [13] Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. znzhang@tongji.edu.cn. [14] Tsingtao Advanced Research Institute, Tongji University, Qingdao, 266071, China. znzhang@tongji.edu.cn. [15] Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. liweida@tongji.edu.cn. [16] Tsingtao Advanced Research Institute, Tongji University, Qingdao, 266071, China. liweida@tongji.edu.cn. [17] Reg-Verse Therapeutics (Shanghai) Co. Ltd., Shanghai, 200120, China. liweida@tongji.edu.cn. [18]
DOI 10.1038/s41380-023-01987-3
PMID 36750736
发布时间 2023-05-28
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