Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.

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作者： Lennart,Brewitz ^[1] ; Leo,Dumjahn ^[1] ; Yilin,Zhao ^[1] ; C David,Owen ^[2] ; Stephen M,Laidlaw ^[3] ; Tika R,Malla ^[4] ; Dung,Nguyen ^[1] ; Petra,Lukacik ^[4] ; Eidarus,Salah ^[2] ; Adam D,Crawshaw ^[3] ; Anna J,Warren ^[1] ; Jose,Trincao ^[2] ; Claire,Strain-Damerell ^[2] ; Miles W,Carroll ^[2] ; Martin A,Walsh ^[2] ; Christopher J,Schofield ^[3]

作者单位： Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom. ^[1] Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot OX11 0DE, United Kingdom. ^[2] Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, United Kingdom. ^[3] Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom. ^[4]

主题词人类(Humans);抗病毒药(Antiviral Agents);半胱氨酸(Cysteine);腈类(Nitriles);病毒非结构蛋白质类(Viral Nonstructural Proteins)

DOI 10.1021/acs.jmedchem.2c01627

PMID 36757959

发布时间 2023-08-31

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