首页> International journal of molecular sciences> Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies.

Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies.

导出 OA

翻译打印收藏纠错

第一作者： Federica,Scalia

第一单位： Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.;Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy.

作者： Federica,Scalia ^[1] ; Giosuè,Lo Bosco ^[2] ; Letizia,Paladino ^[1] ; Alessandra Maria,Vitale ^[1] ; Leila,Noori ^[3] ; Everly,Conway de Macario ^[4] ; Alberto J L,Macario ^[4] ; Fabio,Bucchieri ^[5] ; Francesco,Cappello ^[1] ; Fabrizio,Lo Celso ^[6]

作者单位： Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.;Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy. ^[1] Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy.;Department of Mathematics and Computer Science, University of Palermo, 90123 Palermo, Italy. ^[2] Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy.;Department of Anatomy, School of Medicine, Tehran University of Medical Science, Tehran 1417653911, Iran. ^[3] Euro-Mediterranean Institute of Science and Technology (IEMEST), 90139 Palermo, Italy.;Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD 21202, USA. ^[4] Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy. ^[5] Department of Physics and Chemistry-Emilio Segrè, University of Palermo, 90128 Palermo, Italy.;Ionic Liquids Laboratory, Institute of Structure of Matter, Italian National Research Council (ISM-CNR), 00133 Rome, Italy. ^[6]

关键词 CCT5 CCT5 chaperonopathies CCT5 mutations apical domain chaperone system electrostatic potential hydrogen bonds protein binding

医学主题词伴侣素包含蛋白TCP-1(Chaperonin Containing TCP-1);伴侣蛋白类(Chaperonins);分子伴侣(Molecular Chaperones);分子动力学模拟(Molecular Dynamics Simulation);突变(Mutation)

DOI 10.3390/ijms24032018

PMID 36768350

发布时间 2023-03-01

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交