Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model.

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第一作者： Tianqi,Xu

第一单位： Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

作者： Tianqi,Xu ^[1] ; Alexey,Schulga ^[2] ; Elena,Konovalova ^[3] ; Sara S,Rinne ^[4] ; Hongchao,Zhang ^[1] ; Olga,Vorontsova ^[1] ; Anna,Orlova ^[5] ; Sergey M,Deyev ^[6] ; Vladimir,Tolmachev ^[7] ; Anzhelika,Vorobyeva ^[1]

作者单位： Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden. ^[1] Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Tomsk 634050, Russia.;Molecular Immunology Laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia. ^[2] Molecular Immunology Laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia. ^[3] Department of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden. ^[4] Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Tomsk 634050, Russia.;Department of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.;Science for Life Laboratory, Uppsala University, 751 23 Uppsala, Sweden. ^[5] Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Tomsk 634050, Russia.;Molecular Immunology Laboratory, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia.;Bio-Nanophotonic Laboratory, Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University 'MEPhI', Moscow 115409, Russia.;Center of Biomedical Engineering, Sechenov University, Moscow 119991, Russia. ^[6] Department of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.;Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Tomsk 634050, Russia. ^[7]

关键词 DARPin EpCAM HER3 MM-121 combination treatment pancreatic cancer pseudomonas exotoxin A targeted therapy