Design, Synthesis and Structure-Activity Relationship Studies of Nicotinamide Derivatives as Potent Antifungal Agents by Disrupting Cell Wall.

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第一作者： Tingjunhong,Ni

第一单位： Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, China.

作者： Tingjunhong,Ni ^[1] ; Fei,Xie ^[2] ; Liping,Li ^[1] ; Yumeng,Hao ^[2] ; Xiaochen,Chi ^[3] ; Lan,Yan ^[2] ; Dazhi,Zhang ^[1] ; Yuanying,Jiang ^[2] ; Quanzhen,Lv ^[1]

作者单位： Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, China. ^[1] School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China. ^[2] School of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. ^[3]

关键词 antifungal hit-to-lead nicotinamide structure-activity relationship synthesis

主题词人类(Humans);抗真菌药(Antifungal Agents);烟酰胺(Niacinamide);微生物敏感性试验(Microbial Sensitivity Tests);构效关系(Structure-Activity Relationship);氟康唑(Fluconazole);白色念珠菌(Candida albicans)

DOI 10.3390/molecules28031135

PMID 36770802

发布时间 2023-02-14

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