Pharmacological ascorbate potentiates combination nanomedicines and reduces cancer cell stemness to prevent post-surgery recurrence and systemic metastasis.

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作者： Xiaomin,Jiang ^[1] ; Jianqiao,Liu ^[1] ; Jianming,Mao ^[1] ; Wenbo,Han ^[1] ; Yingjie,Fan ^[1] ; Taokun,Luo ^[1] ; Junjie,Xia ^[1] ; Morten J,Lee ^[1] ; Wenbin,Lin ^[2]

作者单位： Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA. ^[1] Department of Chemistry, The University of Chicago, Chicago, IL, 60637, USA; Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago, 5758, S Maryland Ave, Chicago, IL, 60637, USA. Electronic address: wenbinlin@uchicago.edu. ^[2]

关键词 Cancer stem cells bioresposive nanoparticles chemotherapy pharmacological ascorbate post-surgery recurrence tumor metastasis

主题词动物(Animals);小鼠(Mice);钠米医学(Nanomedicine);抗肿瘤药(Antineoplastic Agents);肿瘤(Neoplasms);肿瘤干细胞(Neoplastic Stem Cells);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1016/j.biomaterials.2023.122037

PMID 36773429

发布时间 2024-04-02

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