Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure.

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作者： Bridget,Simonson ^[1] ; Mark,Chaffin ^[1] ; Matthew C,Hill ^[2] ; Ondine,Atwa ^[1] ; Yasmine,Guedira ^[1] ; Harshit,Bhasin ^[1] ; Amelia W,Hall ^[3] ; Sikander,Hayat ^[4] ; Simon,Baumgart ^[4] ; Kenneth C,Bedi ^[5] ; Kenneth B,Margulies ^[5] ; Carla A,Klattenhoff ^[4] ; Patrick T,Ellinor ^[6]

作者单位： Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ^[1] Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. ^[2] Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Gene Regulation Observatory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ^[3] Precision Cardiology Laboratory, Bayer US, LLC, Cambridge, MA 02142, USA. ^[4] Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[5] Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: ellinor@mgh.harvard.edu. ^[6]

关键词 CP: Molecular biology dilated cardiomyopathy druggable genome heart failure hypertrophic cardiomyopathy ischemic cardiomyopathy single-nucleus RNA sequencing

主题词人类(Humans);内皮细胞(Endothelial Cells);心肌缺血(Myocardial Ischemia);心力衰竭(Heart Failure);心肌病, 扩张型(Cardiomyopathy, Dilated);序列分析, RNA(Sequence Analysis, RNA);心肌疾病(Cardiomyopathies)

DOI 10.1016/j.celrep.2023.112086

PMID 36790929

发布时间 2023-10-24

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