Garlic-derived exosomes regulate PFKFB3 expression to relieve liver dysfunction in high-fat diet-fed mice via macrophage-hepatocyte crosstalk.

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作者： Jinfan,Liu ^[1] ; Weizhao,Li ^[1] ; Yangping,Bian ^[1] ; Xiaoqing,Jiang ^[1] ; Fuyun,Zhu ^[1] ; Fei,Yin ^[2] ; Li,Yin ^[1] ; Xiaomei,Song ^[3] ; Hong,Guo ^[4] ; Jianhui,Liu ^[5]

作者单位： Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China. ^[1] Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China. Electronic address: fyin@cqut.edu.cn. ^[2] Department of Gastroenterology, Chongqing General Hospital, University of Chinese Academy of Sciences, No. 118, Xingguang Avenue, Liangjiang New Area, Chongqing 401147, China. ^[3] Department of Gastroenterology, Chongqing General Hospital, University of Chinese Academy of Sciences, No. 118, Xingguang Avenue, Liangjiang New Area, Chongqing 401147, China. Electronic address: hguo2013@aliyun.com. ^[4] Chongqing Key Laboratory of Medicinal Chemistry and Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China. Electronic address: jhliu@cqut.edu.cn. ^[5]

关键词 Garlic-derived exosomes (GDE)Inflammation Lipid metabolism Nonalcoholic fatty liver disease (NAFLD)Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3)