Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1-RIPK3-MLKL axis.
第一作者:
Fu-Li,Shi
第一单位:
Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
作者:
关键词
Antimycin A (PubChem CID: 14957)Dimethyl fumarateDimethyl fumarate (PubChem CID: 637568)Dimethyl malonate (PubChem CID: 7943)Dimethyl succinate (PubChem CID: 7820)GSK′872 (PubChem CID: 54674134)MLKLMonomethyl fumarate (PubChem CID: 5369209)N-acetyl-L-cysteine (PubChem CID: 12035)NecroptosisNecrostatin-1 (PubChem CID: 2828334)RIPK3Reverse electron transportRotenone (PubChem CID: 6758)Systemic inflammatory response syndrome
医学主题词
小鼠(Mice);动物(Animals);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);蛋白激酶类(Protein Kinases);受体作用蛋白丝氨酸苏氨酸激酶类(Receptor-Interacting Protein Serine-Threonine Kinases);全身炎症反应综合征(Systemic Inflammatory Response Syndrome);氧化磷酸化(Oxidative Phosphorylation);细胞凋亡(Apoptosis)
DOI
10.1016/j.phrs.2023.106697
PMID
36796462
发布时间
2023-03-15
- 浏览1
Pharmacological research
106697页
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