Buddlejasaponin IV induces apoptotic cell death by activating the mitochondrial‑dependent apoptotic pathway and reducing α<sub>2</sub>β<sub>1</sub> integrin‑mediated adhesion in HT‑29 human colorectal cancer cells.

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作者： Jin-Eun,Kim ^[1] ; Sun Kyoung,Lee ^[1] ; Junhee,Park ^[1] ; Min Ju,Jung ^[1] ; So-Eun,An ^[1] ; Hye Ji,Yang ^[1] ; Won-Yoon,Chung ^[1]

作者单位： Department of Oral Biology, Oral Cancer Research Institute, and BK21 FOUR Project INNO‑Dent Convergence Academy, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea. ^[1]

关键词 Akt a2β1 integrin anoikis apoptosis buddlejasaponin IV cell adhesion focal adhesion kinase mitochondrial?dependent

主题词人类(Humans);动物(Animals);小鼠(Mice);HT29细胞(HT29 Cells);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);bcl-2相关X蛋白质(bcl-2-Associated X Protein);细胞凋亡(Apoptosis);黏着斑蛋白酪氨酸激酶类(Focal Adhesion Protein-Tyrosine Kinases);细胞黏附(Cell Adhesion);失巢凋亡(Anoikis);结肠肿瘤(Colonic Neoplasms);整合素类(Integrins)

DOI 10.3892/or.2023.8495

PMID 36799199

发布时间 2023-02-22

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Oncology reports

2023年49卷3期

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Buddlejasaponin IV induces apoptotic cell death by activating the mitochondrial‑dependent apoptotic pathway and reducing α<sub>2</sub>β<sub>1</sub> integrin‑mediated adhesion in HT‑29 human colorectal cancer cells.

Oncology reports

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Oncology reports

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Buddlejasaponin IV induces apoptotic cell death by activating the mitochondrial‑dependent apoptotic pathway and reducing α<sub>2</sub>β<sub>1</sub> integrin‑mediated adhesion in HT‑29 human colorectal cancer cells.

Oncology reports

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Oncology reports

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