Design, synthesis and evaluation of nitric oxide releasing derivatives of 2,4-diaminopyrimidine as novel FAK inhibitors for intervention of metastatic triple-negative breast cancer.

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作者： Jinlin,Zhang ^[1] ; Kangping,Xu ^[1] ; Fei,Yang ^[1] ; Yaoren,Qiu ^[1] ; Jiayi,Li ^[1] ; Jing,Li ^[1] ; Wenxuan,Wang ^[1] ; Guishan,Tan ^[1] ; Zhenxing,Zou ^[2] ; Fenghua,Kang ^[3]

作者单位： Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, PR China. ^[1] Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, PR China. Electronic address: zouzhenxing@csu.edu. ^[2] Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, PR China; Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Central South University, Changsha, PR China. Electronic address: kangfenghua@csu.edu.cn. ^[3]

关键词 2,4-Diaminopyrimidine Anti-metastasis activity FAK inhibitor Nitric oxide Triple-negative breast cancer

主题词人类(Humans);一氧化氮(Nitric Oxide);细胞增殖(Cell Proliferation);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement)

DOI 10.1016/j.ejmech.2023.115192

PMID 36801517

发布时间 2023-03-15

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