Engineered Polymer-siRNA Polyplexes Provide Effective Treatment of Lung Inflammation.

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作者： Taewon,Jeon ^[1] ; David C,Luther ^[2] ; Ritabrita,Goswami ^[2] ; Charlotte,Bell ^[2] ; Harini,Nagaraj ^[3] ; Yagiz Anil,Cicek ^[2] ; Rui,Huang ^[2] ; Javier A,Mas-Rosario ^[2] ; James L,Elia ^[1] ; Jungkyun,Im ^[2] ; Yi-Wei,Lee ^[2] ; Yuanchang,Liu ^[4] ; Federica,Scaletti ^[2] ; Michelle E,Farkas ^[2] ; Jesse,Mager ^[2] ; Vincent M,Rotello ^[1]

作者单位： Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, 230 Stockbridge Road, Amherst, Massachusetts 01003, USA. ^[1] Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. ^[2] Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, 661 N Pleasant Street, Amherst, Massachusetts 01003, USA. ^[3] Department of Chemical Engineering and Department of Electronic Materials, Devices, and Equipment Engineering, Soonchunhyang University, 22 Soonchunhyangro, Asan 31538, Republic of Korea. ^[4]

关键词 Anti-inflammatory cytosolic delivery lung inflammation polymer polyplex siRNA

主题词动物(Animals);小鼠(Mice);RNA, 小分子干扰(RNA, Small Interfering);聚合物(Polymers);RNA, 双链(RNA, Double-Stranded);内颗粒(Endosomes);肺炎(Pneumonia)

DOI 10.1021/acsnano.2c08690

PMID 36802503

发布时间 2024-03-15

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