Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells.

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第一作者： Scott M,Emrich

第一单位： Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, United States.

作者： Scott M,Emrich ^[1] ; Ryan E,Yoast ^[1] ; Xuexin,Zhang ^[1] ; Adam J,Fike ^[2] ; Yin-Hu,Wang ^[3] ; Kristen N,Bricker ^[2] ; Anthony Y,Tao ^[3] ; Ping,Xin ^[4] ; Vonn,Walter ^[5] ; Martin T,Johnson ^[6] ; Trayambak,Pathak ^[1] ; Adam C,Straub ^[4] ; Stefan,Feske ^[5] ; Ziaur S M,Rahman ^[4] ; Mohamed,Trebak ^[5]

作者单位： Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, United States. ^[1] Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, United States. ^[2] Department of Pathology, New York University School of Medicine, New York, United States. ^[3] Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States. ^[4] Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, United States. ^[5] Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, United States. ^[6]

关键词 B cells CRAC channels Orai1 Orai3 SOCE biochemistry cell biology chemical biology metabolism mouse

主题词动物(Animals);小鼠(Mice);B-淋巴细胞(B-Lymphocytes);钙(Calcium);钙通道(Calcium Channels);钙信号(Calcium Signaling)

DOI 10.7554/eLife.84708

PMID 36803766

发布时间 2023-11-06

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