Investigation of nirmatrelvir epimerization occurred in analytical sample solution by using high resolution LC-MS<sup>n</sup>, NMR, and hydrogen/deuterium exchange study.

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第一作者： Lewei,Zheng

第一单位： Center of Excellence for Modern Analytical Technologies (CEMAT) Huahai Pharmaceutical Co., Ltd, Xunqiao, Linhai, Zhejiang 317024, PR China.

作者： Lewei,Zheng ^[1] ; Lingqiao,Wang ^[1] ; Dan,Li ^[1] ; Chongjun,Xie ^[1] ; Zhiyuan,Gao ^[1] ; Jinsheng,Lin ^[1] ; Jian,Ye ^[1] ; Wenbin,Chen ^[1] ; Min,Li ^[2]

作者单位： Center of Excellence for Modern Analytical Technologies (CEMAT) Huahai Pharmaceutical Co., Ltd, Xunqiao, Linhai, Zhejiang 317024, PR China. ^[1] Center of Excellence for Modern Analytical Technologies (CEMAT) Huahai Pharmaceutical Co., Ltd, Xunqiao, Linhai, Zhejiang 317024, PR China; Huahai US, Inc. 700 Atrium Drive, Somerset, NJ 08873, USA. Electronic address: minli88@yahoo.com. ^[2]

关键词 Epimerization Forced degradation Hydrogen/deuterium exchange NMR LC-MS Nirmatrelvir

主题词色谱法, 液相(Chromatography, Liquid);氘(Deuterium);氢(Hydrogen);串联质谱法(Tandem Mass Spectrometry);磁共振波谱学(Magnetic Resonance Spectroscopy);色谱法, 高压液相(Chromatography, High Pressure Liquid);腈类(Nitriles)

DOI 10.1016/j.jpba.2023.115284

PMID 36804289

发布时间 2023-03-20

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