Identification of proteinase 3 autoreactive CD4<sup>+</sup>T cells and their T-cell receptor repertoires in antineutrophil cytoplasmic antibody-associated vasculitis.

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第一作者： Ravi Kumar,Sharma

第一单位： Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Solna, Sweden.

作者： Ravi Kumar,Sharma ^[1] ; Niyaz,Yoosuf ^[1] ; Marcelo,Afonso ^[1] ; Andrea,Scheffschick ^[1] ; Aune,Avik ^[2] ; Alice,Bartoletti ^[3] ; Begum,Horuluoglu ^[1] ; Juan Sebastian,Diaz Boada ^[1] ; Sanjay Kumar,Boddul ^[1] ; Asta Dögg,Jonasdottir ^[4] ; Björn,Lövström ^[5] ; Hanna,Brauner ^[6] ; Bruno,Raposo ^[1] ; Karine,Chemin ^[1] ; Annette,Bruchfeld ^[7] ; Iva,Gunnarsson ^[5] ; Vivianne,Malmström ^[8]

作者单位： Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Solna, Sweden. ^[1] Academic Centre of Specialists, Department of Rheumatology, Stockholm, Sweden. ^[2] Rheumatology Department, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy. ^[3] Division of Renal Medicine, Department of Clinical Science, Intervention and Technology (CLINTEC) Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. ^[4] Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Division of Rheumatology, Karolinska University Hospital, Stockholm, Sweden. ^[5] Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Solna, Sweden; Department of Dermatology, Karolinska University Hospital, Stockholm, Sweden. ^[6] Division of Renal Medicine, Department of Clinical Science, Intervention and Technology (CLINTEC) Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden. ^[7] Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Center for Molecular Medicine, Karolinska Institutet, Solna, Sweden. Electronic address: vivianne.malmstrom@ki.se. ^[8]

关键词 ANCA-associated vasculitis PR3 T cells T-cell receptors autoimmunity

主题词人类(Humans);成髓细胞素(Myeloblastin);抗体, 抗中性白细胞胞质(Antibodies, Antineutrophil Cytoplasmic);抗中性粒细胞胞浆抗体相关性血管炎(Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);过氧化物酶(Peroxidase)

DOI 10.1016/j.kint.2023.01.023

PMID 36804380

发布时间 2023-05-04

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