E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.

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作者： Daniel C,Scott ^[1] ; Moeko T,King ^[2] ; Kheewoong,Baek ^[3] ; Clifford T,Gee ^[4] ; Ravi,Kalathur ^[5] ; Jerry,Li ^[6] ; Nicholas,Purser ^[6] ; Amanda,Nourse ^[5] ; Sergio C,Chai ^[4] ; Sivaraja,Vaithiyalingam ^[5] ; Taosheng,Chen ^[4] ; Richard E,Lee ^[4] ; Stephen J,Elledge ^[7] ; Gary,Kleiger ^[6] ; Brenda A,Schulman ^[8]

作者单位： Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: danny.scott@stjude.org. ^[1] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. ^[2] Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany. ^[3] Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA. ^[4] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Protein Technologies Center, St. Jude Children's Research Hospital, Memphis, TN, USA. ^[5] Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, NV, USA. ^[6] Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA, USA. ^[7] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany. ^[8]