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Membrane lipid remodeling modulates γ-secretase processivity.

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第一作者： Edgar,Dawkins

第一单位： Division of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), LMU Munich, Munich, Germany.

作者： Edgar,Dawkins ^[1] ; Rico J E,Derks ^[2] ; Martina,Schifferer ^[3] ; Johannes,Trambauer ^[1] ; Edith,Winkler ^[1] ; Mikael,Simons ^[4] ; Dominik,Paquet ^[5] ; Martin,Giera ^[2] ; Frits,Kamp ^[1] ; Harald,Steiner ^[6]

作者单位： Division of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), LMU Munich, Munich, Germany. ^[1] Center for Proteomics & Metabolomics, Leiden University Medical Center (LUMC), Leiden, The Netherlands. ^[2] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. ^[3] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany; Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany. ^[4] Munich Cluster of Systems Neurology (SyNergy), Munich, Germany; Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany. ^[5] Division of Metabolic Biochemistry, Faculty of Medicine, Biomedical Center (BMC), LMU Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. Electronic address: harald.steiner@med.uni-muenchen.de. ^[6]

关键词 Alzheimer disease Aβ37/38 amyloid precursor protein (APP) processing amyloid-β peptide (Aβ)erucic acid lipid homeostasis lipidomics membrane thickness presenilin γ-secretase