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Esterase-Activated, pH-Responsive, and Genetically Targetable Nano-Prodrug for Cancer Cell Photo-Ablation.

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第一作者： Pingping,Liang

第一单位： School of Life Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.

作者： Pingping,Liang ^[1] ; Yuanying,Zhang ^[1] ; Brigitte F,Schmidt ^[2] ; Byron,Ballou ^[2] ; Wei,Qian ^[3] ; Ziyi,Dong ^[1] ; Jiahui,Wu ^[1] ; Lingling,Wang ^[4] ; Marcel P,Bruchez ^[2] ; Xiaochen,Dong ^[5]

作者单位： School of Life Sciences, Anhui Medical University, Hefei, Anhui, 230032, China. ^[1] Molecular Biosensor and Imaging Center, Carnegie Mellon University, Mellon Institute, 4400 Fifth Avenue, Pittsburgh, PA, 15213, USA. ^[2] University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. ^[3] Department of general surgery of the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, 230002, China. ^[4] Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211816, China.;School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou, 221116, China. ^[5]

关键词 Mito-FAP dual organelles-targeting esterase-activated mitochondria dysfunction pH-responsive photo-ablation

医学主题词药物前体(Prodrugs);药物释放系统(Drug Delivery Systems);纳米粒子(Nanoparticles);氢离子浓度(Hydrogen-Ion Concentration);细胞系, 肿瘤(Cell Line, Tumor);肿瘤(Neoplasms)

DOI 10.1002/smll.202207535

PMID 36807550

发布时间 2023-05-17

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