Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.

导出 OA

翻译打印收藏纠错

第一作者： Brenda,Amaral

第一单位： Departments of Research, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

作者： Brenda,Amaral ^[1] ; Andrew,Capacci ^[2] ; Trip,Anderson ^[1] ; Ceren,Tezer ^[1] ; Bekim,Bajrami ^[3] ; Mukesh,Lulla ^[4] ; Brian,Lucas ^[2] ; Jayanth V,Chodaparambil ^[5] ; Douglas,Marcotte ^[5] ; P Rajesh,Kumar ^[5] ; Paramasivam,Murugan ^[6] ; Kerri,Spilker ^[5] ; Mike,Cullivan ^[5] ; Ti,Wang ^[6] ; Anton C,Peterson ^[2] ; Istvan,Enyedy ^[2] ; Bin,Ma ^[2] ; TeYu,Chen ^[2] ; Zain,Yousaf ^[2] ; Michael,Calhoun ^[1] ; Olga,Golonzhka ^[1] ; Gregory M,Dillon ^[1] ; Samir,Koirala ^[1]

作者单位： Departments of Research, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States. ^[1] Departments of Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States. ^[2] Departments of Chemical Biology and Proteomics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States. ^[3] Departments of Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States. ^[4] Departments of Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States. ^[5] Departments of Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States. ^[6]

关键词 Alzheimer’s GSK3α GSK3β kinase inhibitor tau β-catenin

主题词糖原合成酶激酶3(Glycogen Synthase Kinase 3);磷酰化(Phosphorylation);细胞增殖(Cell Proliferation)

DOI 10.1021/acschemneuro.2c00476

PMID 36812145

发布时间 2023-04-11

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交