Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription.

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第一作者： Yu-Fei,Wang

第一单位： Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China.;Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.

作者： Yu-Fei,Wang ^[1] ; Jin-Yan,Feng ^[2] ; Li-Na,Zhao ^[1] ; Man,Zhao ^[3] ; Xian-Fu,Wei ^[2] ; Yu,Geng ^[3] ; Hong-Feng,Yuan ^[1] ; Chun-Yu,Hou ^[1] ; Hui-Hui,Zhang ^[1] ; Guo-Wen,Wang ^[4] ; Guang,Yang ^[5] ; Xiao-Dong,Zhang ^[6]

作者单位： Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China.;Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. ^[1] Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.;Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China. ^[2] Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin, 300071, China. ^[3] Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. wangguowen@tmu.edu.cn.;Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China. wangguowen@tmu.edu.cn. ^[4] Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China. yangguang@tjmuch.com.;Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. yangguang@tjmuch.com. ^[5] Department of Gastrointestinal Cancer Biology, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China. zhangxiaodong@tjmuch.com.;Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. zhangxiaodong@tjmuch.com. ^[6]

关键词 NF-κB PDTC SLC7A11 aspirin erastin ferroptosis ferrostatin-1 hepatocellular carcinoma

主题词人类(Humans);癌, 肝细胞(Carcinoma, Hepatocellular);NF-κB(NF-kappa B);肝肿瘤(Liver Neoplasms);阿司匹林(Aspirin);细胞系, 肿瘤(Cell Line, Tumor);氨基酸转运系统y+(Amino Acid Transport System y+)

DOI 10.1038/s41401-023-01062-1

PMID 36829052

发布时间 2024-08-09

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