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Polyphenols with Anti-Inflammatory Properties: Synthesis and Biological Activity of Novel Curcumin Derivatives.

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第一作者： Yisett,González

第一单位： Center for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama.;Sistema Nacional de Investigación (SNI), SENACYT, Panama City 0816-02852, Panama.

作者： Yisett,González ^[1] ; Randy,Mojica-Flores ^[2] ; Dilan,Moreno-Labrador ^[3] ; Luis,Cubilla-Rios ^[4] ; K S Jagannatha,Rao ^[5] ; Patricia L,Fernández ^[1] ; Oleg V,Larionov ^[6] ; Johant,Lakey-Beitia ^[7]

作者单位： Center for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama.;Sistema Nacional de Investigación (SNI), SENACYT, Panama City 0816-02852, Panama. ^[1] Center for Biodiversity and Drug Discovery, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama. ^[2] Center for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama. ^[3] Sistema Nacional de Investigación (SNI), SENACYT, Panama City 0816-02852, Panama.;Laboratory of Tropical Bioorganic Chemistry, Faculty of Natural, Exact Sciences and Technology, University of Panama, Panama City 0824-03366, Panama. ^[4] Center for Neuroscience, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama.;Department of Biotechnology, Koneru Lakshmaiah Education Foundation (KLEF) Deemed to be University, Vaddeswaram 522 302, India. ^[5] Department of Chemistry, The University of Texas at San Antonio, San Antonio, TX 78249, USA. ^[6] Sistema Nacional de Investigación (SNI), SENACYT, Panama City 0816-02852, Panama.;Center for Biodiversity and Drug Discovery, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Clayton, City of Knowledge, Panama City 0843-01103, Panama. ^[7]

关键词 IL-6 PGE2 anti-inflammatory activity curcumin curcumin derivatives cytokine difunctionalized monofunctionalized structure–activity relationship succinate

医学主题词消炎药(Anti-Inflammatory Agents);姜黄素(Curcumin);白细胞介素6(Interleukin-6);构效关系(Structure-Activity Relationship)

DOI 10.3390/ijms24043691

PMID 36835104

发布时间 2023-03-22

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准确一般字义偏差语意偏离译文作用小提交