Endothelial Differentiation of <i>CCM1</i> Knockout iPSCs Triggers the Establishment of a Specific Gene Expression Signature.

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作者： Robin A,Pilz ^[1] ; Dariush,Skowronek ^[1] ; Lara,Mellinger ^[1] ; Sander,Bekeschus ^[2] ; Ute,Felbor ^[1] ; Matthias,Rath ^[1]

作者单位： Department of Human Genetics, University Medicine Greifswald and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, 17475 Greifswald, Germany. ^[1] ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 17489 Greifswald, Germany. ^[2] Department of Human Medicine and Institute for Molecular Medicine, MSH Medical School Hamburg, 20457 Hamburg, Germany. ^[3]

关键词 CCM1/KRIT1 CRISPR/Cas9 genome editing RNA-Seq cerebral cavernous malformation endothelial-specific gene expression iPSC-derived endothelial cells iPSCs

主题词人类(Humans);细胞分化(Cell Differentiation);血管瘤, 海绵状, 中枢神经系统(Hemangioma, Cavernous, Central Nervous System);诱导多能干细胞(Induced Pluripotent Stem Cells);原癌基因蛋白质类(Proto-Oncogene Proteins);肿瘤微环境(Tumor Microenvironment);基因敲除技术(Gene Knockout Techniques)

DOI 10.3390/ijms24043993

PMID 36835400

发布时间 2023-03-31

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