Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-<i>d</i>]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme.

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第一作者： Federica,Poggialini

第一单位： Department of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.

作者： Federica,Poggialini ^[1] ; Chiara,Vagaggini ^[1] ; Annalaura,Brai ^[1] ; Claudia,Pasqualini ^[1] ; Emmanuele,Crespan ^[2] ; Giovanni,Maga ^[2] ; Cecilia,Perini ^[2] ; Noemi,Cabella ^[2] ; Lorenzo,Botta ^[3] ; Francesca,Musumeci ^[4] ; Maria,Frosini ^[5] ; Silvia,Schenone ^[4] ; Elena,Dreassi ^[1]

作者单位： Department of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy. ^[1] Institute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy. ^[2] Department of Ecological and Biological Sciences, University of Tuscia, Via S.C. De Lellis s.n.c., 01100 Viterbo, Italy. ^[3] Department of Pharmacy, University of Genoa, 16132 Genoa, Italy. ^[4] Department of Life Sciences, University of Siena, 53100 Siena, Italy. ^[5]

关键词 ADME antiproliferative activity c-Src/Abl dual inhibitors glioblastoma pyrazolo[3,4-d]pyrimidines tyrosine kinase

DOI 10.3390/pharmaceutics15020453

PMID 36839775

发布时间 2023-03-01

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