Optimization and In Vitro Characterization of Telmisartan Loaded Sodium Alginate Beads and Its In Vivo Efficacy Investigation in Hypertensive Induced Animal Model.

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作者： Ubaidulla,Uthumansha ^[1] ; Kousalya,Prabahar ^[2] ; Dilli Bhai,Gajapathy ^[3] ; Mohamed,El-Sherbiny ^[4] ; Nehal,Elsherbiny ^[5] ; Mona,Qushawy ^[6]

作者单位： Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai 600048, India. ^[1] Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia. ^[2] Formulation Research & Development, Aurobindo Pharma, Hyderabad 500038, India. ^[3] Department of Basic Medical Sciences, College of Medicine, Almaarefa University, Riyadh 13713, Saudi Arabia. ^[4] Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura 35516, Dakahlia, Egypt. ^[5] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia. ^[6] Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Dakahlia, Egypt. ^[7] Department of Pharmaceutics, Faculty of Pharmacy, University of Tabuk, Tabuk 71491, Saudi Arabia. ^[8] Department of Pharmaceutics, Faculty of Pharmacy, Sinai University, Alarish 45511, North Sinai, Egypt. ^[9]

关键词 alginate polymer anti-hypertension bioavailability central composite design gastroretentive beads in vitro buoyancy telmisartan (TEL)

DOI 10.3390/pharmaceutics15020709

PMID 36840031

发布时间 2023-02-28

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