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Randomized trial of inosine for urate elevation in amyotrophic lateral sclerosis.

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第一作者： David,Walk

第一单位： Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA.

作者： David,Walk ^[1] ; Katharine,Nicholson ^[2] ; Eduardo,Locatelli ^[3] ; James,Chan ^[2] ; Eric A,Macklin ^[2] ; Valerie,Ferment ^[1] ; Georgios,Manousakis ^[1] ; Marianne,Chase ^[2] ; Mariah,Connolly ^[4] ; Derek,Dagostino ^[2] ; Meghan,Hall ^[4] ; Joseph,Ostrow ^[2] ; Lindsay,Pothier ^[2] ; Cassandra,Lieberman ^[2] ; Dario,Gelevski ^[2] ; Rebecca,Randall ^[4] ; Alexander V,Sherman ^[2] ; Erin,Steinhart ^[2] ; Daniela Grasso,Walker ^[2] ; Jason,Walker ^[2] ; Hong,Yu ^[2] ; Anne-Marie,Wills ^[2] ; Michael A,Schwarzschild ^[5] ; Anna L,Beukenhorst ^[6] ; Jukka-Pekka,Onnela ^[6] ; James D,Berry ^[2] ; Merit E,Cudkowicz ^[2] ; Sabrina,Paganoni ^[7]

作者单位： Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA. ^[1] Neurological Clinical Research Institute and Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA. ^[2] Department of Neurology, Holy Cross Hospital, Fort Lauderdale, Florida, USA. ^[3] Clinical Research Organization, Barrow Neurological Institute, Phoenix, Arizona, USA. ^[4] Department of Neurology, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Disease, Boston, Massachusetts, USA. ^[5] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. ^[6] Neurological Clinical Research Institute and Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA.;Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, Massachusetts, USA. ^[7]

关键词 amyotrophic lateral sclerosis clinical trial inosine oxidative stress smartphone application

医学主题词人类(Humans);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);尿酸(Uric Acid);回顾性研究(Retrospective Studies);肌苷(Inosine);双盲法(Double-Blind Method)

DOI 10.1002/mus.27807

PMID 36840949

发布时间 2023-04-21

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