Urinary 8-hydroxy-2'-deoxyguanosine levels are elevated in patients with IDH1-wildtype glioblastoma and are associated with tumor recurrence in gliomas.

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作者： Gamze,Tuna ^[1] ; Nazlı Ecem Dal,Bekar ^[2] ; Sertaç,İşlekel ^[3] ; Gül Hüray,İşlekel ^[4]

作者单位： Department of Molecular Medicine, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey. Electronic address: gamze.tuna@deu.edu.tr. ^[1] Department of Medical Biochemistry, Faculty of Medicine, Izmir University of Economics, Izmir, Turkey. ^[2] Department of Neurosurgery, Medicana Hospital, Izmir, Turkey. ^[3] Department of Molecular Medicine, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Medical Biochemistry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. ^[4]

关键词 8,5′-cyclo-2′-deoxyadenosines 8-hydroxy-2′-deoxyguanosine Gliomas Isocitrate dehydrogenase-1 Molecular diagnosis Oxidatively induced DNA damage

主题词人类(Humans);胶质母细胞瘤(Glioblastoma);肿瘤复发, 局部(Neoplasm Recurrence, Local);DNA损伤(DNA Damage);氧化性应激(Oxidative Stress);突变(Mutation);异柠檬酸脱氢酶(Isocitrate Dehydrogenase)

DOI 10.1016/j.dnarep.2023.103463

PMID 36841018

发布时间 2023-04-10

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