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Neoadjuvant plus adjuvant combined or sequenced vemurafenib, cobimetinib and atezolizumab in patients with high-risk, resectable BRAF-mutated and wild-type melanoma: NEO-TIM, a phase II randomized non-comparative study.

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作者单位: Department of Melanoma, Cancer Immunotherapy and Development Therapeutics. Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale" Napoli, Naples, Italy. [1] Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padova, Italy. [2] Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy. [3] Skin Cancer Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy. [4] Immunotherapy and Cell Therapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. [5] Unit of Melanoma Medical Oncology, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [6] Catholic University of the Sacred Heart and Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy. [7] Division of Melanoma Sarcoma and Rare Tumors, IEO European Institute of Oncology IRCCS Milan, Milan, Italy. [8] Medical Oncology Unit, Department of Oncology, Santa Maria Annunziata Hospital, Azienda USL Toscana Centro, Florence, Italy. [9] Melanoma and Skin Cancers Surgery Unit, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale", Napoli, Italy. [10] Fondazione Policlinico Universitario A. Gemelli, IRCCS - Facility of Epidemiology & Biostatistics, Rome, Italy. [11] Department of Pathology and Cytopathology, Istituto Nazionale Tumori IRCCS Fondazione "G. Pascale", Napoli, Italy. [12] Section of Pathology, Department of Health Sciences, University of Florence, Florence, Italy. [13]
DOI 10.3389/fonc.2023.1107307
PMID 36845751
发布时间 2023-02-28
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