Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis.

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作者： Gerard,Muntané ^[1] ; Javier,Vázquez-Bourgon ^[2] ; Ester,Sada ^[3] ; Lourdes,Martorell ^[2] ; Sergi,Papiol ^[4] ; Elena,Bosch ^[5] ; Arcadi,Navarro ^[1] ; Benedicto,Crespo-Facorro ^[2] ; Elisabet,Vilella ^[1]

作者单位： Hospital Universitari Institut Pere Mata, IISPV, Universitat Rovira i Virgili, Reus, Spain. ^[1] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. ^[2] Institut de Biologia Evolutiva (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain. ^[3] Department of Psychiatry, University Hospital Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain. ^[4] Departamento de Medicina y Psiquiatría, Facultad de Medicina, Universidad de Cantabria, Santander, Spain. ^[5] Department of Psychiatry, Institute of Psychiatric Phenomics and Genomics, University Hospital, Ludwig Maximilian University, Munich, Germany. ^[6] Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain. ^[7] Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. ^[8] Barcelonaβeta Brain Research Center, Fundació Pasqual Maragall, Barcelona, Spain. ^[9] Department of Psychiatry, Instituto de Biomedicina de Sevilla (IBiS), University Hospital Virgen del Rocío, Seville, Spain. ^[10]

关键词 BMI first-episode psychosis pleiotropy polygenic risk scores weight gain

主题词人类(Humans);人体质量指数(Body Mass Index);全基因组关联研究(Genome-Wide Association Study);精神病(Psychotic Disorders);危险因素(Risk Factors);体重增长(Weight Gain)

DOI 10.1192/j.eurpsy.2023.9

PMID 36852609

发布时间 2023-03-30

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