Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody.

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作者： Xinyu,Song ^[1] ; Anwen,Xiong ^[2] ; Fengying,Wu ^[2] ; Xuefei,Li ^[2] ; Jing,Wang ^[3] ; Tao,Jiang ^[4] ; Peixin,Chen ^[2] ; Xiaoshen,Zhang ^[1] ; Zhikai,Zhao ^[1] ; Huifang,Liu ^[5] ; Lei,Cheng ^[5] ; Chao,Zhao ^[3] ; Zhehai,Wang ^[3] ; Chaohu,Pan ^[6] ; Xiaoli,Cui ^[7] ; Ting,Xu ^[7] ; Haitao,Luo ^[8] ; Caicun,Zhou ^[9]

作者单位： School of Medicine, Tongji University, Shanghai, China. ^[1] Department of Medical Oncology, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China. ^[2] Department of Lung Cancer and Immunology, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China. ^[3] Clinical research center, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China. ^[4] Department of Pathology, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China. ^[5] Department of Medical Oncology, Shandong Cancer Hospital, Jinan, Shandong, China. ^[6] Shenzhen Engineering Center for Translational Medicine of Precision Cancer Immunodiagnosis and Therapy, YuceBio Technology Co Ltd, Shenzhen, Guangdong, China. ^[7] Alphamab Biopharmaceuticals, Suzhou, Jiangsu, China. ^[8] Shenzhen Engineering Center for Translational Medicine of Precision Cancer Immunodiagnosis and Therapy, YuceBio Technology Co Ltd, Shenzhen, Guangdong, China caicunzhoudr@163.com luoht1985@gmail.com. ^[9] School of Medicine, Tongji University, Shanghai, China caicunzhoudr@163.com luoht1985@gmail.com. ^[10]

关键词 biomarkers, tumor immunotherapy lung neoplasms

主题词人类(Humans);抗体, 双特异性(Antibodies, Bispecific);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);生态系统(Ecosystem);免疫疗法(Immunotherapy);肺肿瘤(Lung Neoplasms);蛋白质组学(Proteomics)

DOI 10.1136/jitc-2022-006234

PMID 36854570

发布时间 2024-01-05

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Journal for immunotherapy of cancer

2023年11卷2期

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Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody.

Journal for immunotherapy of cancer

相似文献

Journal for immunotherapy of cancer

相关期刊

检索历史清除