Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A.

导出 LinkOut

翻译打印收藏纠错

第一作者： Eugenia A,Panova

第一单位： National Research Centre for Epidemiology and Microbiology named after Honorary Academician N F Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russia.

作者： Eugenia A,Panova ^[1] ; Denis A,Kleymenov ^[2] ; Dmitry V,Shcheblyakov ^[3] ; Evgeniia N,Bykonia ^[1] ; Elena P,Mazunina ^[1] ; Alina S,Dzharullaeva ^[1] ; Anastasia N,Zolotar ^[1] ; Artem A,Derkaev ^[1] ; Ilias B,Esmagambetov ^[1] ; Ivan I,Sorokin ^[1] ; Evgeny V,Usachev ^[1] ; Anatoly N,Noskov ^[1] ; Igor A,Ivanov ^[2] ; Timofei S,Zatsepin ^[1] ; Sergey E,Dmitriev ^[1] ; Vladimir A,Gushchin ^[1] ; Boris S,Naroditsky ^[4] ; Denis Y,Logunov ^[5] ; Alexander L,Gintsburg ^[1]

作者单位： National Research Centre for Epidemiology and Microbiology named after Honorary Academician N F Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russia. ^[1] Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia. ^[2] Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia. ^[3] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia. ^[4] Chemistry Department, Lomonosov Moscow State University, Moscow, Russia. ^[5] Department of Virology, Lomonosov Moscow State University, Moscow, Russia. ^[6] Infectiology Department, I. M. Sechenov First Moscow State Medical University, Moscow, Russia. ^[7]

关键词 BoNT/A inhibitor Clostridium botulinum VHH-Fc antibody mRNA platform single-domain antibody

主题词动物(Animals);人类(Humans);小鼠(Mice);肉毒杆菌毒素类, A型(Botulinum Toxins, Type A);疾病大流行(Pandemics);剂量效应关系, 药物(Dose-Response Relationship, Drug)

DOI 10.3389/fimmu.2023.1098302

PMID 36865543

发布时间 2023-03-07

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交