JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors.

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作者： Shinya,Yari ^[1] ; Junichi,Kikuta ^[2] ; Hotaka,Shigyo ^[3] ; Yu,Miyamoto ^[4] ; Daisuke,Okuzaki ^[5] ; Yuki,Furusawa ^[1] ; Masafumi,Minoshima ^[1] ; Kazuya,Kikuchi ^[2] ; Masaru,Ishii ^[2]

作者单位： Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, 565-0871, Japan. ^[1] WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan. ^[2] Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, 565-0871, Japan. jkikuta@icb.med.osaka-u.ac.jp. ^[3] WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan. jkikuta@icb.med.osaka-u.ac.jp. ^[4] Laboratory of Bioimaging and Drug Discovery, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. jkikuta@icb.med.osaka-u.ac.jp. ^[5] Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. ^[6] AbbVie GK, Medical Affairs, Tokyo, Japan. ^[7] Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan. ^[8] Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, 565-0871, Japan. mishii@icb.med.osaka-u.ac.jp. ^[9] WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan. mishii@icb.med.osaka-u.ac.jp. ^[10] Laboratory of Bioimaging and Drug Discovery, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan. mishii@icb.med.osaka-u.ac.jp. ^[11]

关键词 Cell migration Chemokine Inflammatory bone destruction Intravital imaging JAK inhibitor Osteoclast

DOI 10.1186/s41232-023-00268-4

PMID 36869390

发布时间 2023-03-06

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