New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate <i>Staphylococcus aureus</i>.

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第一作者： Martina,Durcik

第一单位： Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, Ljubljana 1000, Slovenia.

作者： Martina,Durcik ^[1] ; Andrej Emanuel,Cotman ^[1] ; Žan,Toplak ^[1] ; Štefan,Možina ^[1] ; Žiga,Skok ^[1] ; Petra Eva,Szili ^[2] ; Márton,Czikkely ^[2] ; Elvin,Maharramov ^[2] ; Thu Hien,Vu ^[2] ; Maria Vittoria,Piras ^[1] ; Nace,Zidar ^[1] ; Janez,Ilaš ^[1] ; Anamarija,Zega ^[1] ; Jurij,Trontelj ^[1] ; Luis A,Pardo ^[3] ; Diarmaid,Hughes ^[4] ; Douglas,Huseby ^[4] ; Tália,Berruga-Fernández ^[4] ; Sha,Cao ^[4] ; Ivailo,Simoff ^[5] ; Richard,Svensson ^[5] ; Sergiy V,Korol ^[6] ; Zhe,Jin ^[6] ; Francisca,Vicente ^[7] ; Maria C,Ramos ^[7] ; Julia E A,Mundy ^[8] ; Anthony,Maxwell ^[8] ; Clare E M,Stevenson ^[8] ; David M,Lawson ^[8] ; Björn,Glinghammar ^[9] ; Eva,Sjöström ^[10] ; Martin,Bohlin ^[10] ; Joanna,Oreskär ^[10] ; Sofie,Alvér ^[10] ; Guido V,Janssen ^[11] ; Geert Jan,Sterk ^[11] ; Danijel,Kikelj ^[1] ; Csaba,Pal ^[2] ; Tihomir,Tomašič ^[1] ; Lucija,Peterlin Mašič ^[1]

作者单位： Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, Ljubljana 1000, Slovenia. ^[1] Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged H-6726, Hungary. ^[2] Max Planck Institute for Multidisciplinary Sciences, Oncophysiology, Hermann-Rein-Str. 3, Göttingen 37075, Germany. ^[3] Department of Medical Biochemistry and Microbiology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden. ^[4] Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) Department of Pharmacy, Uppsala University, Husargatan 3, Uppsala 75123, Sweden. ^[5] Department of Medical Cell Biology, Uppsala University, Husargatan 3, Uppsala 75123, Sweden. ^[6] Fundación Medina, Avenida del Conocimiento 34, Parque Tecnológico Ciencias de la Salud, Granada 18016, Spain. ^[7] Department of Biochemistry and Metabolism, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, U.K. ^[8] Department of Chemical and Pharmaceutical Toxicology, RISE Research Institutes of Sweden, Södertälje 15136, Sweden. ^[9] Department of Chemical Processes and Pharmaceutical Development, RISE Research Institutes of Sweden, Södertälje 15136, Sweden. ^[10] Medicinal Chemistry Division, Vrije Universiteit Amsterdam, De Boelelaan 1108, Amsterdam 1081 HZ, The Netherlands. ^[11]