Programmed Cell Death-1 (PD-1) anchoring to the GPI-linked co-receptor CD48 reveals a novel mechanism to modulate PD-1-dependent inhibition of human T cells.

导出 LinkOut

翻译打印收藏纠错

作者： Della,White ^[1] ; Alexandra,Cote-Martin ^[2] ; Marina,Bleck ^[2] ; Nicole,Garaffa ^[3] ; Abdulsalam,Shaaban ^[3] ; Helen,Wu ^[4] ; Dongmei,Liu ^[4] ; David,Young ^[4] ; Justin,Scheer ^[4] ; Ivo C,Lorenz ^[4] ; Andrew,Nixon ^[4] ; Jay S,Fine ^[2] ; Fergus R,Byrne ^[2] ; M Lamine,Mbow ^[5] ; Miguel E,Moreno-Garcia ^[6]

作者单位： Departments of Immunology and Respiratory Research, USA. Electronic address: della.white@boehringer-ingelheim.com. ^[1] Departments of Immunology and Respiratory Research, USA. ^[2] Cancer Immunology and Immune Modulation, USA. ^[3] Biotherapeutics Discovery. Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06811 USA. ^[4] Departments of Immunology and Respiratory Research, USA; Cancer Immunology and Immune Modulation, USA. ^[5] Departments of Immunology and Respiratory Research, USA. Electronic address: morgarmig@gmail.com. ^[6]

关键词 Immuno-receptor agonism Novel immuno-modulation Programmed Cell Death-1 (PD-1)T cell inhibition

主题词人类(Humans);淋巴细胞活化(Lymphocyte Activation);Jurkat细胞(Jurkat Cells);src族激酶类(src-Family Kinases);细胞凋亡(Apoptosis)

DOI 10.1016/j.molimm.2023.02.007

PMID 36889184

发布时间 2023-04-13

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交