Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.

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作者： Yusuke,Hirata ^[1] ; Ruiqi,Cai ^[2] ; Allen,Volchuk ^[2] ; Benjamin E,Steinberg ^[3] ; Yoshiro,Saito ^[4] ; Atsushi,Matsuzawa ^[1] ; Sergio,Grinstein ^[5] ; Spencer A,Freeman ^[6]

作者单位： Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan. ^[1] Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada. ^[2] Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Neurosciences and Mental Health, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada. ^[3] Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan. ^[4] Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. Electronic address: sergio.grinstein@sickkids.ca. ^[5] Program in Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, Canada. Electronic address: spencer.freeman@sickkids.ca. ^[6]

关键词 GPX4 NINJ1 Piezo1 TRP channels ferroptosis lytic cell death mechanotransduction pyroptosis

主题词阳离子(Cations);谷胱甘肽过氧化酶(Glutathione Peroxidase);脂质过氧化作用(Lipid Peroxidation);过氧化脂质类(Lipid Peroxides);膜蛋白质类(Membrane Proteins)

DOI 10.1016/j.cub.2023.02.060

PMID 36898371

发布时间 2023-04-15

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