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Comparison of sequential and joint nonlinear mixed effects modeling of tumor kinetics and survival following Durvalumab treatment in patients with metastatic urothelial carcinoma.

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第一作者： Ting,Chen

第一单位： Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA.

作者： Ting,Chen ^[1] ; Yanan,Zheng ^[2] ; Lorin,Roskos ^[3] ; Donald E,Mager ^[4]

作者单位： Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA. ^[1] Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, CA, USA.;Gilead Sciences, Foster City, CA, USA. ^[2] Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, South San Francisco, CA, USA.;Exelixis, Alameda, CA, USA. ^[3] Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA. dmager@buffalo.edu.;Enhanced Pharmacodynamics, LLC, Buffalo, NY, USA. dmager@buffalo.edu. ^[4]

关键词 Durvalumab Joint modeling Population modeling Sequential modeling Survival probability Tumor kinetics

医学主题词人类(Humans);癌, 移行细胞(Carcinoma, Transitional Cell);动力学(Kinetics);膀胱肿瘤(Urinary Bladder Neoplasms);抗体, 单克隆(Antibodies, Monoclonal)

DOI 10.1007/s10928-023-09848-w

PMID 36906878

发布时间 2023-08-01

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