TROP2 expression and SN38 antitumor activity in malignant pleural mesothelioma cells provide a rationale for antibody-drug conjugate therapy.

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作者： Luca,Hegedüs ^[1] ; Özlem,Okumus ^[1] ; Fabian,Mairinger ^[2] ; Till,Ploenes ^[1] ; Sebastian,Reuter ^[3] ; Martin,Schuler ^[4] ; Anja,Welt ^[4] ; Silvia,Vega-Rubin-de-Celis ^[5] ; Dirk,Theegarten ^[2] ; Agnes,Bankfalvi ^[2] ; Clemens,Aigner ^[1] ; Balazs,Hegedüs ^[6]

作者单位： Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Tüschener Weg 40, 45239 Essen, Germany. ^[1] Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany. ^[2] Department of Pulmonology, University Medicine Essen - Ruhrlandklinik, University Hospital Essen, University Duisburg-Essen, Tüschener Weg 40, 45239 Essen, Germany. ^[3] Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany. ^[4] Institute of Cell Biology (Cancer Research), University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany. ^[5] Department of Thoracic Surgery, University Medicine Essen - Ruhrlandklinik, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Tüschener Weg 40, 45239 Essen, Germany. Electronic address: balazs.hegedues@rlk.uk-essen.de. ^[6]

关键词 AURKA Malignant pleural mesothelioma SN38 Sacituzumab govitecan TROP2

主题词人类(Humans);细胞系, 肿瘤(Cell Line, Tumor);免疫轭合物(Immunoconjugates);肺肿瘤(Lung Neoplasms);间皮瘤(Mesothelioma);胸膜肿瘤(Pleural Neoplasms);RNA(RNA)

DOI 10.1016/j.lungcan.2023.03.003

PMID 36907051

发布时间 2023-04-12

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