Vacuoles related to tissue neuron-astrocyte ratio and infiltration of macrophages/monocytes contribute to hyperintense brain signals on diffusion-weighted magnetic resonance imaging in sporadic Creutzfeldt-Jakob disease.

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作者： Ayano,Shima ^[1] ; Kenji,Sakai ^[2] ; Fumio,Yamashita ^[3] ; Tsuyoshi,Hamaguchi ^[4] ; Tetsuyuki,Kitamoto ^[5] ; Makoto,Sasaki ^[3] ; Masahito,Yamada ^[6] ; Kenjiro,Ono ^[7]

作者单位： Department of Neurology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-Machi, Kanazawa 920-8640, Japan. ^[1] Department of Neurology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-Machi, Kanazawa 920-8640, Japan; Department of Neurology, Joetsu General Hospital, 616 Daidofukuda, Joetsu, Niigata 943-8507, Japan. Electronic address: itrainbonnet@joetsu-hp.jp. ^[2] Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan. ^[3] Department of Neurology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-Machi, Kanazawa 920-8640, Japan; Department of Neurology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan. ^[4] Department of Neurological Science, Tohoku University Graduate School of Medicine, 2-1 Seiyo-machi, Aoba-ku, Sendai 980-8565, Japan. ^[5] Department of Neurology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-Machi, Kanazawa 920-8640, Japan; Department of Internal Medicine, Division of Neurology, Kudanzaka Hospital, 1-6-12 Kudanzakaminami, Chiyoda-ku, Tokyo 102-0074, Japan. ^[6] Department of Neurology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-Machi, Kanazawa 920-8640, Japan. Electronic address: onoken@med.kanazawa-u.ac.jp. ^[7]

关键词 Creutzfeldt-Jakob disease Diffusion-weighted imaging Hyperintensity Magnetic resonance imaging Vacuoles