Tailored behavioural tests reveal early and progressive cognitive deficits in M1000 prion disease.

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作者： Matteo,Senesi ^[1] ; Victoria,Lewis ^[1] ; Paul A,Adlard ^[2] ; David I,Finkelstein ^[2] ; Jee Hyun,Kim ^[3] ; Steven J,Collins ^[4]

作者单位： Department of Medicine, The University of Melbourne, 30 Royal Parade, Parkville, VIC, Australia. ^[1] Florey Department of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, Australia. ^[2] Florey Department of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, Australia; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia. ^[3] Department of Medicine, The University of Melbourne, 30 Royal Parade, Parkville, VIC, Australia; Florey Department of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, VIC, Australia. Electronic address: stevenjc@unimelb.edu.au. ^[4]

关键词 Barnes maze Behavioural testing Fear condition Infectious disease M1000 Nesting Neurodegeneration Neuroscience Prion

主题词动物(Animals);小鼠(Mice);朊病毒病(Prion Diseases);疾病恶化(Disease Progression);认知(Cognition)

DOI 10.1016/j.nbd.2023.106075

PMID 36914075

发布时间 2023-04-21

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